The cluster of shows in Ireland in mid August, known as The Circuit, takes in some of the loveliest parts of the South West and many take their holidays to co-incide. The first all breed this year was Clonmel and in Glen of Imaal Terriers Bitch Green Star and BOB went to Sw Ch Donvaleset Bonnie Colleen. Dog Green Star and Best Opposite Sex was awarded to Torcan of Carrighglen (Jun Ch). The All Terrier Group Championship Show is held before the circuit….anybody want to share the results?
Within weeks of each other the two organisations declared a breakthrough in the search for the gene that causes PRA in Glen of Imaal Terriers and today, after the epublication from Bochum the full paper from Optigen. They also conclude an ADAM 9 mutation is the cause so provisionally it seems both have found the same thing. The full link to the Bochum paper is here for anybody who wishes to check research and analysis. We should have realised that some of our more learned people would want the full monty rather than the abstract!
Over the past few months the question in the minds of many Glen of Imaal Terrier breeders has been a genetic one. The breed has been so fortunate having two places (Cornell & Bochum) looking in the PRA problem and unbelieveably both declared success but was it the same gene causing the mutation that both had found? The only way to know was when both organisations published; below is the epublication from Bochum.
Generalized progressive retinal atrophy in the Irish Glen of Imaal Terrier is associated with a deletion in the ADAM9 gene.
Department of Human Genetics, Ruhr University, Universitätsstrasse 150, 44801 Bochum, Germany.
Generalized progressive retinal atrophy (gPRA) belongs to a group of inherited retinal diseases which are associated with gradual vision loss in various dog breeds, including the Irish Glen of Imaal Terrier (GIT). By genome-wide homozygosity mapping using SNP arrays and fine mapping of candidate regions, we assigned the gPRA candidate locus in this breed to canine chromosome 16. The respective region is syntenic with human chromosome 8 comprising the ADAM metallopeptidase domain 9 (ADAM9) gene. ADAM9 represents a strong candidate gene for canine retinal disease because mutations have previously been shown to cause autosomal recessively inherited human cone-rod dystrophy, a retinal disorder affecting photoreceptor function. Sequence analysis of ADAM9 in affected and carrier GITs revealed a deletion of exons 15 and 16 which alters the reading frame leading to a premature stop codon. This mutation was absent from 34 other dog breeds. A variable and, at times, very late onset of gPRA was confirmed in GITs by a relatively mild retinal degeneration at an advanced age. Hence, the identification of the genetic defect underlying gPRA in the GIT represents a suitable model for cone-rod dystrophy of humans, with superior potential to elucidate functional consequences of the recently described null mutations in the human ADAM9 gene. Copyright © 2010. Published by Elsevier Ltd.
When having a tea break have a look at this :- Jemima Harrison interviewing Professor Sheila Crispin, the new chairman of the Independent Dog Advisory Council which was formed on the recommendation of the Bateson report
Champion Coleraine’s Mandalay Royalty (Curry) took the record for Glen of Imaal Terrier number one group placements in the USA with another Gp1 and Gp2 over the weekend. In Finland Gleann Organ (Gleann Catmandoo-Marfidal Medb Gleann) added another Best of Breed and so becomes an International Champion. The Glen Association here had a funday; no details yet but hopefully it didn’t rain!
Dr. Gregory Acland, whose research led to the discovery of the crd3 mutation at Cornell University and UPenn, will be at the New England Glen Gathering on Saturday September 18th in Barre, MA. He will be performing eye exams and giving a research update. Optigen will also be there to take samples for the DNA mutation test as part of a 20/20 clinic.
Contact Martha Parry (firstname.lastname@example.org) or Ara Lynn (603-878-3552) for more information.
Hopefully every Glen of Imaal Terrier person now knows that there is a DNA test to identify the mutant gene within the breed that causes PRA. Tests are now coming back to owners and we are honoured that the blog has been asked to run a list of results. This has occured because of the way that the blog, no passwords, no signing in, no joining, is currently the only medium on the internet for Glens freely available to everybody and freely available for everybody to comment on without tracking.
The intention is for the PRA DNA list to appear monthly and results are welcome from ALL. As nobody knows (yet) whether Optigen and Bochum are testing for the same gene names will be listed under the relevant laboratory.
Winnie Wanna Make Music. Normal/Clear
Bundle of Hope Normal/Clear
Jeonty Maybe Daysee Normal/Clear
Ch Jeonty Wannabe Buster Normal/Clear
Ch Jeonty Fern Grass Normal/Clear
Jeonty Wanabee Bauer Carrier
Jeonty Wannabe Gemma Carrier
Jeonty Red Clover Normal/Clear
Jeonty Highlander Boy Carrier
Pajantick Jimmy Mac Normal/Clear
Johnny Be Good at Romainville Normal/Clear
Brockland Belle Bregorrey Carrier
Romainville Brannigan Normal/Clear
Fire & Ice Dino at Jeonty Normal/Clear
Rainbow Springs Oliver Twist Clear
Rainbow Springs Irish Rose Affected
Ch. Rainbow Springs Ansel Adams Normal/Clear
Ch. Rainbow Springs GotaLota Moxie Affected (nealy 10 years old & still clear via opthalmic examination)
Rainbow Springs High Velocity Normal/Clear
Ch. Tipperary Rumor Has It Normal/Clear
GrCh Finnabir Fiona The Wicked Carrier
Ch Finnabair Roisin O Tipperary Normal/Clear
Ch Tipperary Rose of Tralee Normal/Clear
Ch Rainbow Springs Geeruh Laoch Normal/Clear
Ch Rainbow Springs Kylee of Cnoc Normal/Clear
Ch Rainbow Springs Dermot Carrier
Rainbow Springs Arlo Guthrie Normal/Clear
Finnabair Song O’My Heart Carrier
Finnabair The Charm One at Ber-D-Mar Normal/Clear
A new rescue organisation has joined Glen of Imaal Terrier ranks. Glen Rescue (Ireland) has recently opened its Facebook page and asks everybody to note it in their diaries, webpages, puppy packs, online contacts and any and everywhere else it may be of use. The contact person is Marie McNeill telephone 0863267058 email email@example.com